{"id":8317,"date":"2026-01-07T12:39:33","date_gmt":"2026-01-07T15:39:33","guid":{"rendered":"https:\/\/infocuatro.com\/?p=8317"},"modified":"2026-01-07T12:39:36","modified_gmt":"2026-01-07T15:39:36","slug":"un-avance-del-conicet-abre-el-camino-a-marcapasos-mas-inteligentes-y-nuevas-terapias-cardiacas","status":"publish","type":"post","link":"https:\/\/infocuatro.com\/?p=8317","title":{"rendered":"Un avance del CONICET abre el camino a marcapasos m\u00e1s inteligentes y nuevas terapias card\u00edacas"},"content":{"rendered":"\n

El estudio identific\u00f3 un\u00a0rol clave del Nodo Sinusal, conocido como el\u00a0marcapasos natural del coraz\u00f3n<\/em>, en la\u00a0regulaci\u00f3n de la variabilidad del ritmo card\u00edaco, un indicador central de la salud cardiovascular. El trabajo fue publicado en la revista cient\u00edfica Frontiers in Medicine\u00a0y ya impuls\u00f3 el\u00a0desarrollo de un marcapasos innovador con patente argentina.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

El avance, liderado por la investigadora del CONICET Isabel Irurzun, impulsa el dise\u00f1o de un marcapasos m\u00e1s avanzado que ya cuenta con una patente. Cr\u00e9dito: CONICET Fotograf\u00eda<\/em><\/p>\n\n\n\n

Un cambio de paradigma m\u00e9dico<\/strong><\/p>\n\n\n\n

Hasta ahora, la comunidad m\u00e9dica consideraba que la variabilidad del ritmo card\u00edaco depend\u00eda casi exclusivamente del\u00a0Sistema Nervioso Aut\u00f3nomo (SNA). Bajo ese supuesto, la mayor\u00eda de los tratamientos y herramientas diagn\u00f3sticas se dise\u00f1aron para modular ese sistema.<\/p>\n\n\n\n

Sin embargo, bas\u00e1ndose en evidencia cl\u00ednica de\u00a0miles de pacientes e individuos sanos, los investigadores proponen un nuevo modelo: el SNA aporta un est\u00edmulo basal, pero es el\u00a0Nodo Sinusal\u00a0quien\u00a0modula activamente la variabilidad de los latidos. Este enfoque abre nuevas posibilidades para el diagn\u00f3stico y tratamiento de arritmias, miocardiopat\u00edas y la enfermedad del nodo sinusal, entre otras patolog\u00edas.<\/p>\n\n\n\n

El Nodo Sinusal y su estructura fractal<\/strong><\/p>\n\n\n\n

Uno de los hallazgos m\u00e1s relevantes del estudio es que el Nodo Sinusal posee una\u00a0estructura fractal, una arquitectura compleja que evoluciona a lo largo de la vida. El equipo logr\u00f3 identificar\u00a0tres exponentes cr\u00edticos\u00a0que describen matem\u00e1ticamente esa geometr\u00eda.<\/p>\n\n\n\n

A partir de esos par\u00e1metros, los investigadores desarrollaron un modelo capaz de\u00a0predecir c\u00f3mo deber\u00eda evolucionar un Nodo Sinusal sano desde la gestaci\u00f3n hasta la adultez. Las patolog\u00edas que alteran esta estructura se manifestar\u00edan primero como\u00a0cambios en la variabilidad del ritmo card\u00edaco, incluso antes de modificar la frecuencia promedio de los latidos.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

David Alejandro Jorge Tas\u00e9, Ingeniero Biom\u00e9dico y becario doctoral del CONICET, e Isabel Irurzun (izq.) en el Centro de Simulaci\u00f3n Computacional para Aplicaciones Tecnol\u00f3gicas (CSC-CONICET). Cr\u00e9dito: CONICET Fotograf\u00eda\u00a0<\/em><\/p>\n\n\n\n

Fibrosis card\u00edaca y diagn\u00f3stico temprano<\/strong><\/p>\n\n\n\n

El trabajo tambi\u00e9n establece una relaci\u00f3n directa entre la\u00a0fibrosis card\u00edaca\u00a0\u2014el reemplazo de c\u00e9lulas musculares por fibras de col\u00e1geno\u2014, la estructura del Nodo Sinusal y la p\u00e9rdida de variabilidad del ritmo card\u00edaco.<\/p>\n\n\n\n

La investigaci\u00f3n demuestra que la\u00a0red de col\u00e1geno que rodea al Nodo Sinusal\u00a0no solo lo a\u00edsla el\u00e9ctricamente, sino que tambi\u00e9n\u00a0define su estructura fractal. Cuando este entramado se altera, la secuencia de los latidos se ve afectada antes que otros par\u00e1metros, lo que podr\u00eda facilitar\u00a0diagn\u00f3sticos m\u00e1s tempranos y precisos.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

La m\u00e9dica cardi\u00f3loga y electrofisi\u00f3loga Magdalena Defeo tambi\u00e9n es autora del trabajo. Es jefa de Servicio de Cardiolog\u00eda del Hospital Prof. Dr. Rodolfo Rossi, responsable del \u00c1rea de Electrofisiolog\u00eda Card\u00edaca Invasiva del Hospital Italiano de La Plata e integra la Comisi\u00f3n Directiva de la Federaci\u00f3n Argentina de Cardiolog\u00eda.<\/em><\/p>\n\n\n\n

Un marcapasos argentino de nueva generaci\u00f3n<\/strong><\/p>\n\n\n\n

A partir de estos descubrimientos, el equipo est\u00e1 desarrollando un\u00a0marcapasos que incorpora la variabilidad del ritmo card\u00edaco, una caracter\u00edstica ausente en los dispositivos actuales. La invenci\u00f3n ya fue\u00a0patentada en la Argentinapor el CONICET, la UNLP y el Ministerio de Salud de la Provincia de Buenos Aires.<\/p>\n\n\n\n

Los marcapasos convencionales funcionan con una\u00a0estimulaci\u00f3n peri\u00f3dica, lo que puede provocar p\u00e9rdida de variabilidad, remodelaci\u00f3n card\u00edaca y el llamado\u00a0s\u00edndrome de marcapasos<\/em>. El nuevo dispositivo busca\u00a0imitar el comportamiento natural del coraz\u00f3n, preservando la variabilidad y mejorando el gasto card\u00edaco.<\/p>\n\n\n\n

Actualmente se encuentra en desarrollo el\u00a0primer prototipo funcional, con criterios de control y programaci\u00f3n que permitir\u00e1n al m\u00e9dico adaptar el dispositivo a las necesidades de cada paciente.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Juan Carlos Goin, tambi\u00e9n autor del trabajo, investigador del CONICET y jefe del Laboratorio de Farmacolog\u00eda Molecular (LAFAM) en el Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO, CONICET-UBA).<\/em><\/p>\n\n\n\n

Ciencia p\u00fablica con impacto real<\/strong><\/p>\n\n\n\n

Este avance demuestra el potencial de la\u00a0ciencia p\u00fablica argentina\u00a0para generar conocimiento de frontera y transformarlo en\u00a0innovaci\u00f3n tecnol\u00f3gica aplicada, con impacto directo en la salud, la industria biom\u00e9dica y la soberan\u00eda cient\u00edfica.<\/p>\n\n\n\n

El desaf\u00edo que sigue es avanzar en las\u00a0etapas de validaci\u00f3n cl\u00ednica y transferencia tecnol\u00f3gica, para que este desarrollo llegue al sistema de salud y mejore la calidad de vida de miles de personas.<\/p>\n","protected":false},"excerpt":{"rendered":"

El estudio identific\u00f3 un\u00a0rol clave del Nodo Sinusal, conocido como el\u00a0marcapasos natural del coraz\u00f3n, en la\u00a0regulaci\u00f3n de la variabilidad del ritmo card\u00edaco, un indicador central […]<\/p>\n","protected":false},"author":4,"featured_media":8318,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-8317","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nacionales"],"yoast_head":"\nUn avance del CONICET abre el camino a marcapasos m\u00e1s inteligentes y nuevas terapias card\u00edacas - InfoCuatro<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/infocuatro.com\/?p=8317\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un avance del CONICET abre el camino a marcapasos m\u00e1s inteligentes y nuevas terapias card\u00edacas - 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